Study Raises Hope for New Anti-Ageing Drugs

Mar 16, 2013 by Sci-News.com

A new research published in the March 8 issue of the journal Science finally proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans.

SIRT1: broad potential for diseases of aging (© Sirtris)

SIRT1: broad potential for diseases of aging (© Sirtris)

“Drugs that combat ageing may be available within five years,” said study senior author Prof David Sinclair from Harvard Medical School, and the University of New South Wales.

The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators.

The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed.

Although research surrounding resveratrol has been going for a decade, until now the basic science had been contested.

The study shows all of the 117 drugs tested work on the single enzyme through a common mechanism. This means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer’s disease and type 2 diabetes.

“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others. In effect, they would slow ageing,” Prof Sinclair said.

“In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster.”

“Our drugs can mimic the benefits of diet and exercise, but there is no impact on weight,” Prof Sinclair said. “The first therapeutic to be marketed will be for diabetes.”

There have been limited trials in people with type 2 diabetes and the skin inflammatory disease, psoriasis. There were benefits to the metabolism in the first group and a reduction in skin redness in the second.

The drugs can be administered orally, or topically. So far, there have been no drugs developed targeting ageing skin, but one major skin care range has developed a crème with resveratrol in it.

“While any drug would be strictly prescribed for certain conditions, one day, they could be taken orally as a preventative. This would be in much the same way as statin drugs are commonly prescribed to prevent, instead of simply treating, cardiovascular disease.”

In animal models, overweight mice given synthetic resveratrol were able to run twice as far as slim mice and they lived 15 per cent longer.

“Now we are looking at whether there are benefits for those who are already healthy. Things there are also looking promising,” the scientist said.

“We’re finding that ageing isn’t the irreversible affliction that we thought it was,” Prof Sinclair said. “Some of us could live to 150, but we won’t get there without more research.”

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Bibliographic information: Basil P. Hubbard et al. 2013. Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators. Science, vol. 339, no. 6124, pp. 1216-1219; doi: 10.1126/science.1231097